A recent analyst claimed that the days of the ubiquitous mouse are numbered. 40 years old is too old, as newer gesture-based devices, touch-screens, and other paradigms, such as Surface Computing emerge.
We are already beginning to touch our phones, gesture to our games, jump on mats, and pretend-play musical instruments. I do believe that things will change, but I don't expect the mouse to disappear for at least another ten years. Several years ago, I had a bet with a friend that voice interfaces will be ubiquitous by 2010 ... I was wrong. Things move slower than they could.
But...mice seem to have it bad - both in the lab and in the real world!